CD4(+) invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4(+)CD25(+)FoxP3(+) regulatory T cells

Dysregulated donor T cells lead to destruction of host tissues resulting in graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We investigated the impact of highly purified (>95%) donor CD4(+) invariant natural killer T (iNKT) cells on GVHD in a murine mod...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Schneidawind, Dominik, Pierini, Antonio, Alvarez, Maite, Pan, Yuqiong, Baker, Jeanette, Buechele, Corina, Luong, Richard H., Meyer, Everett H., Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239338/
https://ncbi.nlm.nih.gov/pubmed/25293774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-576017
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