TNF-α priming enhances CD4(+)FoxP3(+) regulatory T-cell suppressive function in murine GVHD prevention and treatment

CD4(+)CD25(+)FoxP3(+) regulatory T cells (Tregs) have been shown to effectively prevent graft-versus-host disease (GVHD) when adoptively transferred in murine models of hematopoietic cell transplantation and in phase 1/2 clinical trials. Critical limitations to Treg clinical application are the pauc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Pierini, Antonio, Strober, William, Moffett, Caitlin, Baker, Jeanette, Nishikii, Hidekazu, Alvarez, Maite, Pan, Yuqiong, Schneidawind, Dominik, Meyer, Everett, Negrin, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982455/
https://ncbi.nlm.nih.gov/pubmed/27365424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-711275
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