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Na(+)/H(+) Exchangers Induce Autophagy in Neurons and Inhibit Polyglutamine-Induced Aggregate Formation
In polyglutamine diseases, an abnormally elongated polyglutamine results in protein misfolding and accumulation of intracellular aggregates. Autophagy is a major cellular degradative pathway responsible for eliminating unnecessary proteins, including polyglutamine aggregates. Basal autophagy constit...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836979/ https://ncbi.nlm.nih.gov/pubmed/24278418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081313 |
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