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Oxidative stress–dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration

Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an activator of the ubiquiti...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Wakatsuki, Shuji, Furuno, Akiko, Ohshima, Makiko, Araki, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657170/
https://ncbi.nlm.nih.gov/pubmed/26572622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201506102
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