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GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration

Macroautophagy is a catabolic process, in which portions of cytoplasm or organelles are delivered to lysosomes for degradation. Emerging evidence has indicated a pathological connection between axonal degeneration and autophagy. However, the physiological function and induction mechanism of autophag...

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Bibliographic Details
Published in:J Cell Biol
Main Authors: Wakatsuki, Shuji, Tokunaga, Shinji, Shibata, Megumi, Araki, Toshiyuki
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294778/
https://ncbi.nlm.nih.gov/pubmed/28053206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201606020
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