Oxidative stress–dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration

Oxidative stress is a well-known inducer of neuronal apoptosis and axonal degeneration. We previously showed that the E3 ubiquitin ligase ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B activation. We now demonstrate that oxidative stress serves as an activator of the ubiquiti...

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Vydáno v:J Cell Biol
Hlavní autoři: Wakatsuki, Shuji, Furuno, Akiko, Ohshima, Makiko, Araki, Toshiyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657170/
https://ncbi.nlm.nih.gov/pubmed/26572622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201506102
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