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Protein Misfolding and Aggregation as a Therapeutic Target for Polyglutamine Diseases

The polyglutamine (polyQ) diseases, such as Huntington’s disease and several types of spinocerebellar ataxias, are a group of inherited neurodegenerative diseases that are caused by an abnormal expansion of the polyQ tract in disease-causative proteins. Proteins with an abnormally expanded polyQ str...

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Vydáno v:Brain Sci
Hlavní autoři: Takeuchi, Toshihide, Nagai, Yoshitaka
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5664055/
https://ncbi.nlm.nih.gov/pubmed/29019918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci7100128
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