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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in which Ub-conjugated substrates are deubiquitinated,...
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| Publié dans: | Exp Mol Med |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351408/ https://ncbi.nlm.nih.gov/pubmed/25766616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2014.117 |
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