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Synthesis of Plantazolicin Analogues Enables Dissection of Ligand Binding Interactions of a Highly Selective Methyltransferase

[Image: see text] A convergent strategy for the synthesis of truncated analogues of plantazolicin (PZN), a member of the thiazole/oxazole-modified microcin (TOMM) class of natural products, has been developed. These N-terminal mono-, tri- and pentazole substructures of PZN were utilized to probe the...

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Autors principals: Sharma, Abhishek, Blair, Patricia M., Mitchell, Douglas A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836752/
https://ncbi.nlm.nih.gov/pubmed/24063702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol402444a
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