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Inducible Overexpression of GLUT1 Prevents Mitochondrial Dysfunction and Attenuates Structural Remodeling in Pressure Overload but Does Not Prevent Left Ventricular Dysfunction

BACKGROUND: Increased glucose transporter 1 (GLUT1) expression and glucose utilization that accompany pressure overload‐induced hypertrophy (POH) are believed to be cardioprotective. Moreover, it has been shown that lifelong transgenic overexpression of GLUT1 in the heart prevents cardiac dysfunctio...

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Autors principals: Pereira, Renata O., Wende, Adam R., Olsen, Curtis, Soto, Jamie, Rawlings, Tenley, Zhu, Yi, Anderson, Steven M., Dale Abel, E.
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3835233/
https://ncbi.nlm.nih.gov/pubmed/24052497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000301
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