Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function

During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1α (PGC-1α) is repressed in concert with reduced mitochondrial oxidative capacity and fatty acid oxidation (FAO). We therefore sought to determine if maintaining or increasing PGC-1α levels in the context of pres...

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Detalhes bibliográficos
Main Authors: Pereira, Renata O., Wende, Adam R., Crum, Ashley, Hunter, Douglas, Olsen, Curtis D., Rawlings, Tenley, Riehle, Christian, Ward, Walter F., Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101649/
https://ncbi.nlm.nih.gov/pubmed/24776744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-253823
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