PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy: PGC-1β and Pressure Overload

RATIONALE: Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents with reduced PGC-1α expression. OBJECTIVE: To determine the role of PGC-1β...

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Main Authors: Riehle, Christian, Wende, Adam R, Zaha, Vlad G, Pires, Karla Maria, Wayment, Benjamin, Olsen, Curtis, Bugger, Heiko, Buchanan, Jonathan, Wang, Xiaohui, Moreira, Annie Bello, Doenst, Torsten, Medina-Gomez, Gema, Litwin, Sheldon E, Lelliott, Christopher J, Vidal-Puig, Antonio, Abel, E. Dale
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175248/
https://ncbi.nlm.nih.gov/pubmed/21799152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.243964
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