Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

Glucose enters the heart via GLUT1 and GLUT4 glucose transporters. GLUT4-deficient mice develop striking cardiac hypertrophy and die prematurely. Whether their cardiac changes are caused primarily by GLUT4 deficiency in cardiomyocytes or by metabolic changes resulting from the absence of GLUT4 in sk...

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Main Authors: Abel, E. Dale, Kaulbach, Helen C., Tian, Rong, Hopkins, James C.A., Duffy, John, Doetschman, Thomas, Minnemann, Timo, Boers, Mary-Ellen, Hadro, Ed, Oberste-Berghaus, Corinna, Quist, William, Lowell, Bradford B., Ingwall, Joanne S., Kahn, Barbara B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC409881/
https://ncbi.nlm.nih.gov/pubmed/10606624
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