A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Subtype-selective agents for the dopamine D3 receptor (D3R) have been considered as potential medications for drug addiction and other neuropsychiatric disorders. Medicinal chemistry efforts have led to the discovery of 4-phenylpiperazine derivatives that are >100-fold selective for the dopamine...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Michino, Mayako, Donthamsetti, Prashant, Beuming, Thijs, Banala, Ashwini, Duan, Lihua, Roux, Thomas, Han, Yang, Trinquet, Eric, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2013
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834143/
https://ncbi.nlm.nih.gov/pubmed/24061855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087833
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares