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Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants

The studies presented here explore the relationship between protein packing and molecular flexibility using ligand-binding cavity mutants of T4 lysozyme. Although previously reported crystal structures of the mutants investigated show single conformations that are similar to the WT protein, site-dir...

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Bibliografische gegevens
Hoofdauteurs: López, Carlos J., Yang, Zhongyu, Altenbach, Christian, Hubbell, Wayne L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832024/
https://ncbi.nlm.nih.gov/pubmed/24167295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318754110
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