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Conformational selection and adaptation to ligand binding in T4 lysozyme cavity mutants
The studies presented here explore the relationship between protein packing and molecular flexibility using ligand-binding cavity mutants of T4 lysozyme. Although previously reported crystal structures of the mutants investigated show single conformations that are similar to the WT protein, site-dir...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3832024/ https://ncbi.nlm.nih.gov/pubmed/24167295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1318754110 |
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