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Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme

Ligand binding sites in proteins are often localized to deeply buried cavities, inaccessible to bulk solvent. Yet, in many cases binding of cognate ligands occurs rapidly. An intriguing system is presented by the L99A cavity mutant of T4 Lysozyme (T4L L99A) that rapidly binds benzene (~10(6) M(-1)s(...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Mondal, Jagannath, Ahalawat, Navjeet, Pandit, Subhendu, Kay, Lewis E., Vallurupalli, Pramodh
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979041/
https://ncbi.nlm.nih.gov/pubmed/29775455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006180
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