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Atomistic picture of conformational exchange in a T4 lysozyme cavity mutant: an experiment-guided molecular dynamics study

Despite the importance of dynamics to protein function there is little information about the states that are formed as the protein explores its conformational landscape or about the mechanism by which transitions between the different states occur. Here we used a combined NMR spin relaxation and unb...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Vallurupalli, Pramodh, Chakrabarti, Nilmadhab, Pomès, Régis, Kay, Lewis E.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008728/
https://ncbi.nlm.nih.gov/pubmed/30008994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03886c
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