Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E

Among various isoforms of Apolipoprotein E (ApoE), the E4 isoform (ApoE4) is considered to be the strongest risk factor for Alzheimer’s disease, whereas the E3 isoform (ApoE3) is neutral to the disease. Interestingly, the sequence of ApoE4 differs from its wild-type ApoE3 by a single amino acid C112...

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Vydáno v:Biophys J
Hlavní autoři: Ray, Angana, Ahalawat, Navjeet, Mondal, Jagannath
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770556/
https://ncbi.nlm.nih.gov/pubmed/29262361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.006
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