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Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E
Among various isoforms of Apolipoprotein E (ApoE), the E4 isoform (ApoE4) is considered to be the strongest risk factor for Alzheimer’s disease, whereas the E3 isoform (ApoE3) is neutral to the disease. Interestingly, the sequence of ApoE4 differs from its wild-type ApoE3 by a single amino acid C112...
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| Publicado en: | Biophys J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5770556/ https://ncbi.nlm.nih.gov/pubmed/29262361 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.10.006 |
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