Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme

Ligand binding sites in proteins are often localized to deeply buried cavities, inaccessible to bulk solvent. Yet, in many cases binding of cognate ligands occurs rapidly. An intriguing system is presented by the L99A cavity mutant of T4 Lysozyme (T4L L99A) that rapidly binds benzene (~10(6) M(-1)s(...

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Detaylı Bibliyografya
Yayımlandı:PLoS Comput Biol
Asıl Yazarlar: Mondal, Jagannath, Ahalawat, Navjeet, Pandit, Subhendu, Kay, Lewis E., Vallurupalli, Pramodh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5979041/
https://ncbi.nlm.nih.gov/pubmed/29775455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006180
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