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Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron–electron resonance
The dominance of a single native state for most proteins under ambient conditions belies the functional importance of higher-energy conformational states (excited states), which often are too sparsely populated to allow spectroscopic investigation. Application of high hydrostatic pressure increases...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3977274/ https://ncbi.nlm.nih.gov/pubmed/24707053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403179111 |
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