ROS1 Immunohistochemistry for Detection of ROS1-Rearranged Lung Adenocarcinomas

ROS1 gene rearrangements are reported in 1–2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS1 rearrangements can be detected using fluorescence in situ hybridization (FISH) however immunohistochemistry (IHC) for ROS1 pro...

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Main Authors: Sholl, Lynette M., Sun, Heather, Butaney, Mohit, Zhang, Chengsheng, Lee, Charles, Jänne, Pasi A., Rodig, Scott J.
格式: Artigo
語言:Inglês
出版: 2013
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831351/
https://ncbi.nlm.nih.gov/pubmed/23887156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0b013e3182960fa7
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