Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK- Rearranged Lung Adenocarcinomas

INTRODUCTION: ALK gene rearrangements occur in ~5% of lung adenocarcinomas (ACA), leading to ALK overexpression and predicting response to targeted therapy. Fluorescence in situ hybridization (FISH) is the gold standard for detection of ALK rearrangements in lung ACA but requires specialized equipme...

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Bibliographic Details
Main Authors: Sholl, Lynette M., Weremowicz, Stanislawa, Gray, Stacy W., Wong, Kwok-Kin, Chirieac, Lucian R., Lindeman, Neal I., Hornick, Jason L.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573350/
https://ncbi.nlm.nih.gov/pubmed/23407557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31827db604
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