A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

PURPOSE: Approximately 5% of lung adenocarcinomas harbor an EML4-ALK gene fusion and define a unique tumor group that may be responsive to targeted therapy. However ALK-rearranged lung adenocarcinomas are difficult to detect by either standard fluorescence in-situ hybridization (FISH) or immunohisto...

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Main Authors: Mino-Kenudson, Mari, Chirieac, Lucian R., Law, Kenny, Hornick, Jason L., Lindeman, Neal, Mark, Eugene J., Cohen, David W., Johnson, Bruce E., Jänne, Pasi A., Iafrate, A. John, Rodig, Scott J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831135/
https://ncbi.nlm.nih.gov/pubmed/20179225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2845
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