Screening of ROS1 Rearrangements in Lung Adenocarcinoma by Immunohistochemistry and Comparison with ALK Rearrangements

ROS1 rearrangement is a predictive biomarker for response to the tyrosine kinase inhibitor, crizotinib. We investigated the usefulness of ROS1 immunohistochemistry (IHC) for the detection of patients who harbor ROS1 rearrangements in two separate cohorts. We also compared ROS1 IHC with ALK IHC in te...

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Bibliografiske detaljer
Main Authors: Cha, Yoon Jin, Lee, Jae Seok, Kim, Hye Ryun, Lim, Sun Min, Cho, Byoung Chul, Lee, Chang Young, Shim, Hyo Sup
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109990/
https://ncbi.nlm.nih.gov/pubmed/25058391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103333
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