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Screening of ROS1 Rearrangements in Lung Adenocarcinoma by Immunohistochemistry and Comparison with ALK Rearrangements

ROS1 rearrangement is a predictive biomarker for response to the tyrosine kinase inhibitor, crizotinib. We investigated the usefulness of ROS1 immunohistochemistry (IHC) for the detection of patients who harbor ROS1 rearrangements in two separate cohorts. We also compared ROS1 IHC with ALK IHC in te...

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Autori principali: Cha, Yoon Jin, Lee, Jae Seok, Kim, Hye Ryun, Lim, Sun Min, Cho, Byoung Chul, Lee, Chang Young, Shim, Hyo Sup
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109990/
https://ncbi.nlm.nih.gov/pubmed/25058391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103333
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