Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
In Alzheimer disease (AD) the microtubule-associated protein tau is redistributed exponentially into paired helical filaments (PHFs) forming neurofibrillary tangles, which correlate with pyramidal cell destruction and dementia. Amorphous neuronal deposits and PHFs in AD are characterized by aggregat...
Збережено в:
| Опубліковано в:: | Proc Natl Acad Sci U S A |
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| Автори: | , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
National Academy of Sciences
1996
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.11213 |
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