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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

In Alzheimer disease (AD) the microtubule-associated protein tau is redistributed exponentially into paired helical filaments (PHFs) forming neurofibrillary tangles, which correlate with pyramidal cell destruction and dementia. Amorphous neuronal deposits and PHFs in AD are characterized by aggregat...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Wischik, C M, Edwards, P C, Lai, R Y, Roth, M, Harrington, C R
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38310/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855335/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.11213
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