Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

In Alzheimer disease (AD) the microtubule-associated protein tau is redistributed exponentially into paired helical filaments (PHFs) forming neurofibrillary tangles, which correlate with pyramidal cell destruction and dementia. Amorphous neuronal deposits and PHFs in AD are characterized by aggregat...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Wischik, C M, Edwards, P C, Lai, R Y, Roth, M, Harrington, C R
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1996
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38310/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.11213
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