Hydrogen Peroxide–Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse Heart

BACKGROUND: A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum (SR) calcium uptake and relaxation due to decreased SR calcium ATPase (SERCA) activity. We tested the hypothesis that H(2)O(2)‐mediated oxidation of SERCA contributes to impaired myocyte relaxation in aging. ME...

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Bibliographische Detailangaben
Hauptverfasser: Qin, Fuzhong, Siwik, Deborah A., Lancel, Steve, Zhang, Jingmei, Kuster, Gabriela M., Luptak, Ivan, Wang, Lei, Tong, Xiaoyong, Kang, Y. James, Cohen, Richard A., Colucci, Wilson S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828801/
https://ncbi.nlm.nih.gov/pubmed/23963753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000184
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