Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674

Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part via activation of SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the molecular mechanism, adult rat ventricular myocytes were exposed to HNO derived from Angeli’s salt. HNO increased the maximal rate of thapsi...

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Hauptverfasser: Lancel, Steve, Zhang, Jingmei, Evangelista, Alicia, Trucillo, Mario P., Tong, XiaoYong, Siwik, Deborah A., Cohen, Richard A., Colucci, Wilson S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046805/
https://ncbi.nlm.nih.gov/pubmed/19265039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.188441
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