Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674

Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part via activation of SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the molecular mechanism, adult rat ventricular myocytes were exposed to HNO derived from Angeli’s salt. HNO increased the maximal rate of thapsi...

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Main Authors: Lancel, Steve, Zhang, Jingmei, Evangelista, Alicia, Trucillo, Mario P., Tong, XiaoYong, Siwik, Deborah A., Cohen, Richard A., Colucci, Wilson S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046805/
https://ncbi.nlm.nih.gov/pubmed/19265039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.188441
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