Hydrogen Peroxide–Mediated SERCA Cysteine 674 Oxidation Contributes to Impaired Cardiac Myocyte Relaxation in Senescent Mouse Heart

BACKGROUND: A hallmark of aging of the cardiac myocyte is impaired sarcoplasmic reticulum (SR) calcium uptake and relaxation due to decreased SR calcium ATPase (SERCA) activity. We tested the hypothesis that H(2)O(2)‐mediated oxidation of SERCA contributes to impaired myocyte relaxation in aging. ME...

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Detalhes bibliográficos
Main Authors: Qin, Fuzhong, Siwik, Deborah A., Lancel, Steve, Zhang, Jingmei, Kuster, Gabriela M., Luptak, Ivan, Wang, Lei, Tong, Xiaoyong, Kang, Y. James, Cohen, Richard A., Colucci, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828801/
https://ncbi.nlm.nih.gov/pubmed/23963753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000184
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