Redox-Mediated Reciprocal Regulation of SERCA and Na(+)/Ca(2+)-Exchanger Contributes to SR Ca(2+)-Depletion in Cardiac Myocytes

Myocardial failure is associated with increased oxidative stress and abnormal excitation-contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca(2+)-stores and a reduction in Ca(2+)-transient amplitude. Little is known about the mechanisms whereby oxidative stress affects C...

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Main Authors: Kuster, Gabriela M., Lancel, Steve, Zhang, Jingmei, Communal, Catherine, Trucillo, Mario P., Lim, Chee C., Pfister, Otmar, Weinberg, Ellen O., Cohen, Richard A., Liao, Ronglih, Siwik, Deborah A., Colucci, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847633/
https://ncbi.nlm.nih.gov/pubmed/20132882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.01.038
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