Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

The thymic medulla represents a key site for the induction of T cell tolerance. In particular, autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) provide a spectrum of tissue-restricted Ags that, through both direct presentation and cross-presentation by dendritic cells...

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Autores principales: White, Andrea J., Nakamura, Kyoko, Jenkinson, William E., Saini, Manoj, Sinclair, Charles, Seddon, Benedict, Narendran, Parth, Pfeffer, Klaus, Nitta, Takeshi, Takahama, Yousuke, Caamano, Jorge H., Lane, Peter J. L., Jenkinson, Eric J., Anderson, Graham
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826119/
https://ncbi.nlm.nih.gov/pubmed/20861360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002151
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