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CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens
Immature double-positive thymocytes are generated in the thymic cortex, and on positive selection, are induced to differentiate into mature single-positive thymocytes and relocate to the medulla. CCR7 is pivotal for cortex-to-medulla migration of positively selected thymocytes, and CCR7-mediated mig...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761327/ https://ncbi.nlm.nih.gov/pubmed/19805112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906956106 |
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