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The impact of negative selection on thymocyte migration in the medulla
Developing thymocytes are screened for self-reactivity before exiting the thymus, but how thymocytes scan the medulla for self-antigens is unclear. Using two-photon microscopy, we observed that medullary thymocytes migrated rapidly and made frequent, transient contacts with dendritic cells. In the p...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793676/ https://ncbi.nlm.nih.gov/pubmed/19543275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1761 |
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