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The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
A key role of the thymic medulla is to negatively select autoreactive CD4(+) and CD8(+) thymocytes, a process important for T cell tolerance induction. However, the involvement of the thymic medulla in other aspects of αβ T cell development, including the generation of Foxp3(+) natural regulatory T...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3620359/ https://ncbi.nlm.nih.gov/pubmed/23530124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122070 |
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