RANK signals from CD4(+)3(−) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities. Here we demonstrate a novel role for a CD4(+)3(−) inducer cell populatio...

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Detalhes bibliográficos
Main Authors: Rossi, Simona W., Kim, Mi-Yeon, Leibbrandt, Andreas, Parnell, Sonia M., Jenkinson, William E., Glanville, Stephanie H., McConnell, Fiona M., Scott, Hamish S., Penninger, Josef M., Jenkinson, Eric J., Lane, Peter J.L., Anderson, Graham
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Brief Definitive Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118623/
https://ncbi.nlm.nih.gov/pubmed/17502664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062497
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