Osteoprotegerin-Mediated Homeostasis of Rank(+) Thymic Epithelial Cells Does Not Limit Foxp3(+) Regulatory T Cell Development

In the thymus, medullary thymic epithelial cells (mTEC) regulate T cell tolerance via negative selection and Foxp3(+) regulatory T cell (Treg) development, and alterations in the mTEC compartment can lead to tolerance breakdown and autoimmunity. Both the receptor activator for NF-κB (RANK)/RANK liga...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: McCarthy, Nicholas I., Cowan, Jennifer E., Nakamura, Kyoko, Bacon, Andrea, Baik, Song, White, Andrea J., Parnell, Sonia M., Jenkinson, Eric J., Jenkinson, William E., Anderson, Graham
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Immune System Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560491/
https://ncbi.nlm.nih.gov/pubmed/26254339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501226
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