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Natural Th17 cells are critically regulated by functional medullary thymic microenvironments
The thymic medulla is critical for the enforcement of central tolerance. In addition to deletion of auto-reactive T-cells, the thymic medulla supports the maturation of heterogeneous natural αβT-cells linked to tolerance mechanisms. Natural IL-17-secreting CD4(+)αβT-cells (nTh17) represent recently...
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| Veröffentlicht in: | J Autoimmun |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Academic Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570931/ https://ncbi.nlm.nih.gov/pubmed/26143957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.06.008 |
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