The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development

A key role of the thymic medulla is to negatively select autoreactive CD4(+) and CD8(+) thymocytes, a process important for T cell tolerance induction. However, the involvement of the thymic medulla in other aspects of αβ T cell development, including the generation of Foxp3(+) natural regulatory T...

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Hlavní autoři: Cowan, Jennifer E., Parnell, Sonia M., Nakamura, Kyoko, Caamano, Jorge H., Lane, Peter J.L., Jenkinson, Eric J., Jenkinson, William E., Anderson, Graham
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2013
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620359/
https://ncbi.nlm.nih.gov/pubmed/23530124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122070
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