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Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction

BACKGROUND: Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that titin’s tandem Ig segment plays in stiffness generation...

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Bibliografiset tiedot
Päätekijät: Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822017/
https://ncbi.nlm.nih.gov/pubmed/23709671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.001268
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