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Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction

BACKGROUND: Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that titin’s tandem Ig segment plays in stiffness generation...

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書誌詳細
主要な著者: Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822017/
https://ncbi.nlm.nih.gov/pubmed/23709671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.001268
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