Shortening of Titin’s Elastic Tandem Ig Segment Leads to Diastolic Dysfunction

BACKGROUND: Diastolic dysfunction is a poorly understood but clinically pervasive syndrome that is characterized by increased diastolic stiffness. Titin is the main determinant of cellular passive stiffness. However, the physiological role that titin’s tandem Ig segment plays in stiffness generation...

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Détails bibliographiques
Auteurs principaux: Chung, Charles S, Hutchinson, Kirk R, Methawasin, Mei, Saripalli, Chandra, Smith, John E, Hidalgo, Carlos G, Luo, Xiuju, Labeit, Siegfried, Guo, Caiying, Granzier, Henk L
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822017/
https://ncbi.nlm.nih.gov/pubmed/23709671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.001268
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