Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase

Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activation of ghrelin, a secreted metabolism-regulating peptide hormone. Although GOAT is a potential therapeutic target for the treatment of obesity and diabetes and plays a key role in other physiologic processe...

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Autores principales: Taylor, Martin S., Ruch, Travis R., Hsiao, Po-Yuan, Hwang, Yousang, Zhang, Pingfeng, Dai, Lixin, Huang, Cheng Ran Lisa, Berndsen, Christopher E., Kim, Min-Sik, Pandey, Akhilesh, Wolberger, Cynthia, Marmorstein, Ronen, Machamer, Carolyn, Boeke, Jef D., Cole, Philip A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820860/
https://ncbi.nlm.nih.gov/pubmed/24045953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510313
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