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Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells

Facioscapulohumeral muscular dystrophy is a dominantly inherited myopathy associated with chromatin relaxation of the D4Z4 macrosatellite array on chromosome 4. DUX4 is encoded within each unit of the D4Z4 array where it is normally transcriptionally silenced and packaged as constitutive heterochrom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Block, Gregory J., Narayanan, Divya, Amell, Amanda M., Petek, Lisa M., Davidson, Kathryn C., Bird, Thomas D., Tawil, Rabi, Moon, Randall T., Miller, Daniel G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820129/
https://ncbi.nlm.nih.gov/pubmed/23821646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt314
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