Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells

Facioscapulohumeral muscular dystrophy is a dominantly inherited myopathy associated with chromatin relaxation of the D4Z4 macrosatellite array on chromosome 4. DUX4 is encoded within each unit of the D4Z4 array where it is normally transcriptionally silenced and packaged as constitutive heterochrom...

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Main Authors: Block, Gregory J., Narayanan, Divya, Amell, Amanda M., Petek, Lisa M., Davidson, Kathryn C., Bird, Thomas D., Tawil, Rabi, Moon, Randall T., Miller, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820129/
https://ncbi.nlm.nih.gov/pubmed/23821646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt314
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