Asymmetric Bidirectional Transcription from the FSHD-Causing D4Z4 Array Modulates DUX4 Production

Facioscapulohumeral Disease (FSHD) is a dominantly inherited progressive myopathy associated with aberrant production of the transcription factor, Double Homeobox Protein 4 (DUX4). The expression of DUX4 depends on an open chromatin conformation of the D4Z4 macrosatellite array and a specific haplot...

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Main Authors: Block, Gregory J., Petek, Lisa M., Narayanan, Divya, Amell, Amanda M., Moore, James M., Rabaia, Natalia A., Tyler, Ashlee, van der Maarel, Silvere M., Tawil, Rabi, Filippova, Galina N., Miller, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334996/
https://ncbi.nlm.nih.gov/pubmed/22536400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035532
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