Bispecific small molecule–antibody conjugate targeting prostate cancer

Bispecific antibodies, which simultaneously target CD3 on T cells and tumor-associated antigens to recruit cytotoxic T cells to cancer cells, are a promising new approach to the treatment of hormone-refractory prostate cancer. Here we report a site-specific, semisynthetic method for the production o...

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Hauptverfasser: Kim, Chan Hyuk, Axup, Jun Y., Lawson, Brian R., Yun, Hwayoung, Tardif, Virginie, Choi, Sei Hyun, Zhou, Quan, Dubrovska, Anna, Biroc, Sandra L., Marsden, Robin, Pinstaff, Jason, Smider, Vaughn V., Schultz, Peter G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816437/
https://ncbi.nlm.nih.gov/pubmed/24127589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316026110
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