Bispecific small molecule–antibody conjugate targeting prostate cancer

Bispecific antibodies, which simultaneously target CD3 on T cells and tumor-associated antigens to recruit cytotoxic T cells to cancer cells, are a promising new approach to the treatment of hormone-refractory prostate cancer. Here we report a site-specific, semisynthetic method for the production o...

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Detalhes bibliográficos
Main Authors: Kim, Chan Hyuk, Axup, Jun Y., Lawson, Brian R., Yun, Hwayoung, Tardif, Virginie, Choi, Sei Hyun, Zhou, Quan, Dubrovska, Anna, Biroc, Sandra L., Marsden, Robin, Pinstaff, Jason, Smider, Vaughn V., Schultz, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816437/
https://ncbi.nlm.nih.gov/pubmed/24127589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316026110
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