Bispecific small molecule–antibody conjugate targeting prostate cancer

Bispecific antibodies, which simultaneously target CD3 on T cells and tumor-associated antigens to recruit cytotoxic T cells to cancer cells, are a promising new approach to the treatment of hormone-refractory prostate cancer. Here we report a site-specific, semisynthetic method for the production o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kim, Chan Hyuk, Axup, Jun Y., Lawson, Brian R., Yun, Hwayoung, Tardif, Virginie, Choi, Sei Hyun, Zhou, Quan, Dubrovska, Anna, Biroc, Sandra L., Marsden, Robin, Pinstaff, Jason, Smider, Vaughn V., Schultz, Peter G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816437/
https://ncbi.nlm.nih.gov/pubmed/24127589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316026110
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