Targeting Human C-Type Lectin-Like Molecule-1 (CLL1) with a Bispecific Antibody for Acute Myeloid Leukemia Immunotherapy

Acute myeloid leukemia (AML), the most common acute adult leukemia and the second most common pediatric leukemia, still has a poor prognosis. Human C-type lectin-like molecule-1 (CLL1) is a recently identified myeloid lineage restricted cell surface marker, which is overexpressed in over 90% of AML...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Lu, Hua, Zhou, Quan, Deshmukh, Vishal, Phull, Hardeep, Ma, Jennifer, Tardif, Virginie, Naik, Rahul R., Bouvard, Claire, Zhang, Yong, Choi, Seihyun, Lawson, Brian R., Zhu, Shoutian, Kim, Chan Hyuk, Schultz, Peter G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280064/
https://ncbi.nlm.nih.gov/pubmed/25056598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201405353
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