Minor Groove Binding Compounds That Jump a GC Base Pair and Bind to Adjacent AT Base Pair Sites()

Most A/T specific heterocyclic diamidine derivatives need at least four A/T base pairs for tight binding to the DNA minor groove. Addition of a GC base pair to A/T sequences typically causes a large decrease in binding constant. The ability to target biologically important sequences of DNA could be...

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Hauptverfasser: Rahimian, Maryam, Kumar, Arvind, Say, Martial, Bakunov, Stanislav A., Boykin, David W., Tidwell, Richard R., Wilson, W. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816085/
https://ncbi.nlm.nih.gov/pubmed/19173620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801944g
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